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KMID : 1145120160140010066
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Asian Journal of Beauty and Cosmetology
2016 Volume.14 No. 1 p.66 ~ p.76
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Antioxidant and Antiwrinkle Effects of Amentoflavone for Cosmetic Materials Development
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Lee Song-Jeong
An Sung-Kwan
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Abstract
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Purpose: This study aimed to investigate the potential of amentoflavone as an antiaging material for cosmetics through examining antioxidant and antiwrinkle effects.
Methods: To check the antioxidant and antiwrinkle effects of amentoflavone, we performed various experiments such as in vitro antioxidant assays, quantitative real-time PCR, SA-β-galactosidase assay, and DCF-DA assay.
Results: We confirmed that the cell viability of amentoflavone is increased in cytotoxic condition. Amentoflavone also had an antioxidant effect like BHT. The expression in mRNA level of antioxidant enzymes such as SOD1 and CAT was increased in a dose-dependent manner. In case of wrinkle, the expression in mRNA level of MMP1 and MMP3 was decreased but the expression of COL1A1 was dose-dependently increased. Also, amentoflavone markedly reduced the expression of SA-β-galactosidase.
Conclusion: As mentioned above, we found that amentoflavone had effects on preventing skin aging and thought that amentoflavone can be a valulable material for antiaging cosmetics.
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KEYWORD
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Amentoflavone, Antioxidant, Human Dermal Fibroblast, Collagen, Senescence
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